Smita Sampath, PhD

Assistant Professor of Diagnostic Radiology

Contact

Address:
Yale University, School of Medicine
Magnetic Resonance Research Center
TAC, N131, 300 Cedar Street
New Haven, Connecticut 06520-8043
United States

Email: smita.sampath@yale.edu
Telephone: (203) 737-5398
Fax: (203) 785-6643

Education

PhD, Electrical Engineering, Johns Hopkins University, 2004

Please click here for Curriculum Vitae

Research Interests

Developing novel magnetic resonance (MR) imaging and post-processing methods related to cardio-vascular medicine. Current research projects include quantification of myocardial strain, quantification of blood velocity patterns within the heart chambers, imaging vascular morphology and intra-vascular flow, and imaging valve dynamics.

Below are some projects in which I am currently involved:

The role of microvascular obstruction in LV remodeling post myocardial infarction and reperfusion: We propose to explore the structural and functional mechanisms that lead to infarct expansion post myocardial infarction and reperfusion, with a specific focus in identifying the contributory role of microvascular obstruction. The presence of microvascular obstruction in reperfused infarcts is a strong independent predictor of poor long-term prognosis, and is associated with heart failure (HF). We are developing novel MR imaging methods that quantify and characterize these events serially in pre-clinical animal studies, with eventual translation into a patient population.

Develop MR imaging methods to quantify three dimensional strains in the left ventricle: The regional quantification of 3-D strain in the left ventricle has a wide range of compelling clinical applications; however, currently available methods are not ideally suited for clinical translation. We are developing high temporal resolution free breathing approaches to quantify regional strains in three dimensions based on MR tagging and harmonic phase (HARP) imaging principles.   

Selected Publications

1. Sampath S., Osman N.F., Prince J.L. Magnetic Resonance Imaging July10, (2008).
2. Sampath S., Kim J. H., Lederman R.J., McVeigh E.R. Journal of Magnetic Resonance Imaging 27(4): 809-817 (2008).
3. Ledesma-Carbayo M.J., Derbyshire J. A., Sampath S., Santos A, Desco M, McVeigh E. R. Magnetic Resonance in Medicine 59(1): 181-189 (2008).
4. Abd-Elmoniem K, Sampath S., Osman N.F., Prince J.L. IEEE Transactions on Biomedical Engineering 54(9): 1650-1656 (2007).
5. Derbyshire J.A., Sampath S., McVeigh E.R. Magnetic Resonance in Medicine 58(1): 206-210 (2007).
6. Sampath S., Raval A. N., Lederman R. J., McVeigh E. R. Magnetic Resonance in Medicine 57(1): 40-49 (2007).
7. Sampath S., Prince J.L. Magnetic Resonance Imaging 25(2): 197-208 (2007).
8. Sampath S., Derbyshire A., Osman N.F., Atalar E., Prince J.L. Magnetic Resonance in Medicine 50:154-163 (2003).
9. Kraitchman D.L., Sampath S., Castillo E., Derbyshire A., Bluemke D.A., Gerber B., Prince J.L., Osman N.F. Circulation 107(15):2025-2030 (2003).
10. Osman N.F., Sampath S., Atalar E., Prince J.L. Magnetic Resonance in Medicine 46:234-334 (2001).

For a further list of Sampath's publications, please see PubMed.

Current and Former Trainees

• Ziheng Zhang (Post-Doctoral Fellow)
• David Brotman (Summer Research Trainee)