Jinghua Wang, Ph.D.
Research Scientist, Diagnostic Radiology
Yale University School of Medicine
Ph.D. in physics from Institute of Physics,
Since the advent of MRI and MRS utilization in biomedicine, the development of technological and methodological advances to improve the sensitivity, spatial resolution and temporal resolution of human biomedical image has become increasingly crucial. At ultra high field, MRI scanner will produce better SNR to obtain clearer, more precise images of the brain, tumors, organs or other structures in the body. These expected benefits, however, are limited by inhomogeneous static magnetic field, radio-frequency field and large special absorption rate (SAR). My long term plan is to develop the techniques to overcome these technical difficulties, improve quantification of MRI parameters (signal intensity, relaxation time, perfusion and BOLD and metabolism concentration), and enable physicians to more accurately diagnose and treat patients, especially in ultra high field.
Areas of research which I focus on include:
Ø
Implementing
computer simulation for optimal coil design, RF shimming, and interaction
between human tissue and radiofrequency field at ultra high field (>3.0 T).
Ø
Investigating
signal intensity and noise in MRI for improving the accuracy and precision of
MR quantification at low SNR, such as perfusion, blood volume and BOLD.
Ø
Developing
new methodology for rapidly and accurately estimating relaxation time (T1 and
T2).
Ø
Investigating new contrasts based on the electromagnetic
properties of human tissues via MRI technique.
Selected Peer
Reviewed
1.
Wang
J, Mao W, Qiu M,
2.
Wang
J, Qiu M, Kim
H, Constable RT. T1
Measurements Incorporating Flip Angle Calibration and Correction In Vivo. ( J
Magn. Reson. 2006,
in press).
3.
Yang QX, Mao W, Wang
J, Smith MB, X Zhang, Ugurbil K, W Chen. Manipulation of Image Intensity
Distribution at 7.0 T: Passive RF Shimming and Focusing with Dielectric
Materials. J Magn Reson. Inamging. J Magn Reson Imaging. 2006;24:197-202.
4.
Wang
J, Qiu M, Yang QX,
5.
Wang
J, Qiu M, Constable
RT. A Method For Rapid And
Effective Correction Of Signal Intensity Nonuniformities With Phased Array
Coils In Vivo. Magn. Reson. Med.
2005;53:666-674.
6.
Yang QX, Wang
J, Collins CM, Smith MB, Zhang X, Ugurbil K, Chen W. Phantom Design Method
For High-Field Mri Human Systems. Magn.
Reson. Med. 2004; 52:1016-1020
7.
Zheng J, Wang J, Rowold F,
Gropler RJ, Woodard PK. Relationship Of Apparent Myocardial T2 And
Oxygenation: Towards Quantification Of Myocardial Oxygen Extraction Fraction. J Magn Reson Imaging. 2004;20:233-241.
8.
Zheng J, Wang J, Nolte M, Rowold F, Yablonskiy DA, Woodard PK, Li D, Gropler
RJ. Myocardial
Oxygenation Mapping With T2 Contrast MRI: A Preliminary Study. Magn. Reson. Med. 2004;51:718-726.
9.
Collins CM, Liu
WZ, Wang J, Gruetter R,
10.
Wang J, Yang QX,
Collins CM, Smith MB, Zhang X, Liu H, Adriany G, Zhu XH, Vaughan JT, Ugurbil
K, Chen W. Analysis Of The RF Field Of A Quadrature Surface Coil At 7 T. Magn
Reson. Med. 2002;48:362-369.
11.
Yang QX, Wang J, Zhang X, Collins CM, Smith MB, Liu H, Zhu XH, Michaeli S,
Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K, Chen W. An Analysis Of
Wave Behavior In Lossy Dielectric Samples At High Field. Magn Reson. Med 2002;47:982-989.
12.
Collins CM, Yang
QX, Wang J, Zhang X, Liu H,
Michaeli S, Zhu XH, Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K,
Smith MB, Chen W. A Verification Of Reciprocity For High-Fields Systems:
Agreement Between Theory And Experiment In A Head-Sized Spherical Phantom
Excited With A Surface Coil At 300 Mhz. Magn
Reson. Med. 2002;47:1026-1028.
13.
Bus SA, Yang QX,
Wang J,
